Oxcia’s CEO Ulrika Warpman Berglund created large interest with the poster presentation of the unique dual mechanism of action of OXC-101 and its potent and well tolerated anti-cancer effects at the 6th Annual DDR Inhibitors Summit in Boston. The conference gave a comprehensive overview of the DDR space (DDR is short for DNA Damage Response – and refers to the processes the body uses to repair the damage that occurs to DNA), with many world class speakers sharing preclinical and clinical updates as well as discussing combination studies with DDR inhibitors, possible solutions to improving patient selection and overcoming the large toxicity problem. Oxcia’s OXC-101 has several advantages in these areas. It is believed to be effective, in mono and combination therapy, for a large target patient population and be well-tolerated. Finding the treatment alternative with the best therapeutic index (the highest benefit with lowest toxicity) is the ultimate goal.
Latest news
-
En ny studie, ” Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model” (fritt översatt: Farmakologisk OGG1-hämning minskar akut lungskada och lungfibros i möss), publicerades den 26 Januari i Nature Communications ( https://doi.org/10.1038/s41467-023-36314-5, L. Tanner, A. B. Single, R. K. V. Bhongir , M. Heusel , T. Mohanty, C. A. Q. Karlsson, L. Pan, C-M. Clausson, J. Bergwik, K. Wang, C. K. Andersson, R. M. Oommen, J. S. Erjefält, J. Malmström, O. Wallner, I. Boldogh, T. Helleday, C. Kalderén & A. Egesten) visar att OXC-201 (TH5487) kan vara en lovande behandling för idiopatisk lungfibros (IPF).
-
A new study, “Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model” (freely translated: Pharmacological OGG1 inhibition reduces acute lung injury and lung fibrosis in mice), was published on January 26 in Nature Communications ( https://doi.org/10.1038/s41467-023-36314-5, L. Tanner, A. B. Single, R. K. V. Bhongir , M. Heusel , T. Mohanty, C. A. Q. Karlsson, L. Pan, C-M. Clausson, J. Bergwik , K. Wang, C. K. Andersson, R. M. Oommen, J. S. Erjefält, J. Malmström, O. Wallner, I. Boldogh, T. Helleday, C. Kalderén & A. Egesten) shows that OXC-201 (TH5487) may be a promising treatment for idiopathic pulmonary fibrosis (IPF).
-
Oxcia är mycket glada över att kunna meddela att EIC (European Innovation Council) har valt ut Oxcias OXC-201 som ett av de projekt som får bidrag inom EIC Transition programmet. Oxcia erhåller ett belopp på 2,5 miljoner euro. EIC är… Continue reading EIC har tilldelat Oxcia AB ett bidrag på 2,5 miljoner euro inom EIC-Transition programmet för utveckling av OXC-201